Nucleotide excision repair pathway polymorphisms and pancreatic cancer risk: evidence for role of MMS19L.

ABSTRACT:

Background

Nucleotide excision repair is a vital response to DNA damage, including damage from tobacco exposure. Single nucleotide polymorphisms (SNP) in the nucleotide excision repair pathway may encode alterations that affect DNA repair function and therefore influence the risk of pancreatic cancer development.

Methods

A clinic-based case-control study in non-Hispanic white persons compared 1,143 patients with pancreatic adenocarcinoma with 1,097 healthy controls. Twenty-seven genes directly and indirectly involved in the nucleotide excision repair pathway were identified and 236 tag-SNPs were selected from 26 of these (one had no SNPs identified). Association studies were done at the gene level by principal components analysis, whereas recursive partitioning analysis was

SUBMITTER: McWilliams RR 

PROVIDER: S-EPMC2710767 | biostudies-literature | 2009 Apr

REPOSITORIES: biostudies-literature