Robustness and fragility in the yeast high osmolarity glycerol (HOG) signal-transduction pathway.

ABSTRACT: Cellular signalling networks integrate environmental stimuli with the information on cellular status. These networks must be robust against stochastic fluctuations in stimuli as well as in the amounts of signalling components. Here, we challenge the yeast HOG signal-transduction pathway with systematic perturbations in components' expression levels under various external conditions in search for nodes of fragility. We observe a substantially higher frequency of fragile nodes in this signal-transduction pathway than that has been observed for other cellular processes. These fragilities disperse without any clear pattern over biochemical functions or location in pathway topology and they are largely independent of pathway activation by external stimuli. However, the strongest toxicities are

SUBMITTER: Krantz M 

PROVIDER: S-EPMC2710867 | biostudies-literature | 2009

REPOSITORIES: biostudies-literature