Comparative systems biology of human and mouse as a tool to guide the modeling of human placental pathology.

ABSTRACT: Placental abnormalities are associated with two of the most common and serious complications of human pregnancy, maternal preeclampsia (PE) and fetal intrauterine growth restriction (IUGR), each disorder affecting approximately 5% of all pregnancies. An important question for the use of the mouse as a model for studying human disease is the degree of functional conservation of genetic control pathways from human to mouse. The human and mouse placenta show structural similarities, but there have been no systematic attempts to assess their molecular similarities or differences. We collected protein and mRNA expression data through shot-gun proteomics and microarray expression analysis of the highly vascular exchange region, microdissected from the human and mouse near-term placenta. Over 700

SUBMITTER: Cox B 

PROVIDER: S-EPMC2710868 | biostudies-literature | 2009

REPOSITORIES: biostudies-literature