Bioinformatic analysis of xenobiotic reactive metabolite target proteins and their interacting partners.

ABSTRACT:

Background

Protein covalent binding by reactive metabolites of drugs, chemicals and natural products can lead to acute cytotoxicity. Recent rapid progress in reactive metabolite target protein identification has shown that adduction is surprisingly selective and inspired the hope that analysis of target proteins might reveal protein factors that differentiate target- vs. non-target proteins and illuminate mechanisms connecting covalent binding to cytotoxicity.

Results

Sorting 171 known reactive metabolite target proteins revealed a number of GO categories and KEGG pathways to be significantly enriched in targets, but in most cases the classes were too large, and the "percent coverage" too small, to allow meaningful conclusions about mechanisms of toxicity. However, a similar

SUBMITTER: Fang J 

PROVIDER: S-EPMC2711050 | biostudies-literature | 2009 Jun

REPOSITORIES: biostudies-literature