Gene expression profiling of intestinal regeneration in the sea cucumber.

ABSTRACT:

Background

Among deuterostomes, the regenerative potential is maximally expressed in echinoderms, animals that can quickly replace most injured organs. In particular, sea cucumbers are excellent models for studying organ regeneration since they regenerate their digestive tract after evisceration. However, echinoderms have been sidelined in modern regeneration studies partially because of the lack of genome-wide profiling approaches afforded by modern genomic tools.For the last decade, our laboratory has been using the sea cucumber Holothuria glaberrima to dissect the cellular and molecular events that allow for such amazing regenerative processes. We have already established an EST database obtained from cDNA libraries of normal and regenerating intestine at two different regenerat

SUBMITTER: Ortiz-Pineda PA 

PROVIDER: S-EPMC2711116 | biostudies-literature | 2009 Jun

REPOSITORIES: biostudies-literature