Evidence that mechanosensors with distinct biomechanical properties allow for specificity in mechanotransduction.

ABSTRACT: Various cell types can sense and convert mechanical forces into biochemical signaling events through a process called mechanotransduction, and this process is often highly specific to the types of mechanical forces applied. However, the mechanism(s) that allow for specificity in mechanotransduction remain undefined. Thus, the goal of this study was to gain insight into how cells distinguish among specific types of mechanical information. To accomplish this goal, we determined if skeletal myoblasts can distinguish among differences in strain, strain rate, and strain-time integral (STI). Our results demonstrate that mechanically induced signaling through the c-jun N-terminal kinase 2 [JNK2] is elicited via a mechanism that depends on an interaction between the magnitude of strain and strain

SUBMITTER: Frey JW 

PROVIDER: S-EPMC2711371 | biostudies-literature | 2009 Jul

REPOSITORIES: biostudies-literature