A brief bout of exercise alters gene expression and distinct gene pathways in peripheral blood mononuclear cells of early- and late-pubertal females.

ABSTRACT: Recent studies show that brief exercise alters circulating neutrophil and peripheral blood mononuclear cell (PBMC) gene expression, ranging from cell growth to both pro-and anti-inflammatory processes. These initial observations were made solely in males, but whether PBMC gene expression is altered by exercise in females is not known. Ten early-pubertal girls (8-11 yr old) and 10 late-pubertal girls (15-17 yr old) performed ten 2-min bouts of cycle ergometry ( approximately 90% peak heart rate) interspersed with 1-min rest intervals. Blood was obtained at rest and after exercise, and microarrays were performed in each individual subject. RNA was hybridized to Affymetrix U133+2.0 Arrays. Exercise induced significant changes in PBMC gene expression in early (1,320 genes)- and late (877 genes

SUBMITTER: Radom-Aizik S 

PROVIDER: S-EPMC2711785 | biostudies-literature | 2009 Jul

REPOSITORIES: biostudies-literature