Mitochondrial haplogroups and control region polymorphisms are not associated with prostate cancer in Middle European Caucasians.

ABSTRACT:

Background

Besides being responsible for energy production in the cell, mitochondria are central players in apoptosis as well as the main source of harmful reactive oxygen species. Therefore, it can be hypothesised that sequence variation in the mitochondrial genome is a contributing factor to the etiology of diseases related to these different cellular events, including cancer. The aim of the present study was to assess the frequency of haplogroups and polymorphisms in the control region (CR) of mitochondrial DNA of peripheral blood mononuclear cells from patients with prostate carcinoma (n = 304) versus patients screened for prostate disease but found to be negative for cancer on biopsy (n = 278) in a Middle European population.

Methodology/principal findings

The nine majo

SUBMITTER: Mueller EE 

PROVIDER: S-EPMC2712094 | biostudies-literature | 2009 Jul

REPOSITORIES: biostudies-literature