Analysis of single nucleotide polymorphisms in the FAS and CTLA-4 genes of peripheral T-cell lymphomas.
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ABSTRACT:
SUBMITTER: Bonzheim I
PROVIDER: S-EPMC2712330 | biostudies-literature | 2008 Jul
REPOSITORIES: biostudies-literature
Publications
Analysis of single nucleotide polymorphisms in the FAS and CTLA-4 genes of peripheral T-cell lymphomas.
Bonzheim Irina I Geissinger Eva E Chuang Wen-Yu WY Roth Sabine S Ströbel Philipp P Marx Alexander A Reimer Peter P Wilhelm Martin M Puppe Bernhard B Rosenwald Andreas A Müller-Hermelink Hans Konrad HK Rüdiger Thomas T
Journal of hematopathology 20080424 1
Angioimmunoblastic T-cell lymphoma (AILT) represents a subset of T-cell lymphomas but resembles an autoimmune disease in many of its clinical aspects. Despite the phenotype of effector T-cells and high expression of FAS and CTLA-4 receptor molecules, tumor cells fail to undergo apoptosis. We investigated single nucleotide polymorphisms (SNPs) of the FAS and CTLA-4 genes in 94 peripheral T-cell lymphomas. Although allelic frequencies of some FAS SNPs were enriched in AILT cases, none of these occ ...[more]
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