Using microarrays to identify positional candidate genes for QTL: the case study of ACTH response in pigs.

ABSTRACT:

Background

Microarray studies can supplement QTL studies by suggesting potential candidate genes in the QTL regions, which by themselves are too large to provide a limited selection of candidate genes. Here we provide a case study where we explore ways to integrate QTL data and microarray data for the pig, which has only a partial genome sequence. We outline various procedures to localize differentially expressed genes on the pig genome and link this with information on published QTL. The starting point is a set of 237 differentially expressed cDNA clones in adrenal tissue from two pig breeds, before and after treatment with adrenocorticotropic hormone (ACTH).

Results

Different approaches to localize the differentially expressed (DE) genes to the pig genome showed different

SUBMITTER: Jouffe V 

PROVIDER: S-EPMC2712744 | biostudies-literature | 2009 Jul

REPOSITORIES: biostudies-literature