A Bayesian hierarchical model for analysis of SNP diversity in multilocus, multipopulation samples.

ABSTRACT: The distribution of genetic variation among populations is conveniently measured by Wright's F(ST), which is a scaled variance taking on values in [0,1]. For certain types of genetic markers, and for single-nucleotide polymorphisms (SNPs) in particular, it is reasonable to presume that allelic differences at most loci are selectively neutral. For such loci, the distribution of genetic variation among populations is determined by the size of local populations, the pattern and rate of migration among those populations, and the rate of mutation. Because the demographic parameters (population sizes and migration rates) are common across all autosomal loci, locus-specific estimates of F(ST) will depart from a common distribution only for loci with unusually high or low rates of mutation or for

SUBMITTER: Guo F 

PROVIDER: S-EPMC2713112 | biostudies-literature | 2009 Mar

REPOSITORIES: biostudies-literature