Treatment of severe amblyopia with weekend atropine: results from 2 randomized clinical trials.

ABSTRACT:

Purpose

To determine the effectiveness of weekend atropine for severe amblyopia from strabismus, anisometropia, or both combined among children 3 to 12 years of age.

Methods

We enrolled children into 2 prospective, randomized multicenter clinical trials of amblyopia therapy. Herein we report the results for severe amblyopia, 20/125 to 20/400. In Trial 1, 60 children 3 to 6 years of age (mean, 4.4 years) were randomized to weekend atropine plus a plano lens or weekend atropine plus full spectacle correction for the sound eye. In Trial 2, 40 children 7 to 12 years of age (mean, 9.3 years) were randomized to weekend atropine or 2 hours of daily patching. The visual acuity outcome was assessed at 18 weeks in Trial 1 and 17 weeks in Trial 2.

Results

In Trial 1, visual acui

SUBMITTER: Repka MX 

PROVIDER: S-EPMC2713117 | biostudies-literature | 2009 Jun

REPOSITORIES: biostudies-literature