Identification of essential sequences for cellular localization in BRMS1 metastasis suppressor.

ABSTRACT:

Background

Breast cancer metastasis suppressor 1 (BRMS1) reduces the number and the size of secondary tumours in a mouse model without affecting the growth of the primary foci upon its re-expression. Knockdown of BRMS1 expression associates with metastasis. The molecular details on BRMS1 mechanism of action include its ability to function as a transcriptional co-repressor and consistently BRMS1 has been described as a predominantly nuclear protein. Since cellular distribution could represent a potential mechanism of regulation, we wanted to characterize BRMS1 sequence motifs that might regulate its cellular distribution. According to its amino acids sequence, BRMS1 contain two putative nuclear localization signals, however none of them has been proved to work so far.

Methodology

SUBMITTER: Rivera J 

PROVIDER: S-EPMC2713406 | biostudies-literature | 2009 Jul

REPOSITORIES: biostudies-literature