Preclinical assessment of the treatment of second-stage African trypanosomiasis with cordycepin and deoxycoformycin.

ABSTRACT:

Background

There is an urgent need to substitute the highly toxic compounds still in use for treatment of the encephalitic stage of human African trypanosomiasis (HAT). We here assessed the treatment with the doublet cordycepin and the deaminase inhibitor deoxycoformycin for this stage of infection with Trypanosoma brucei (T.b.).

Methodology/principal findings

Cordycepin was selected as the most efficient drug from a direct parasite viability screening of a compound library of nucleoside analogues. The minimal number of doses and concentrations of the drugs effective for treatment of T.b. brucei infections in mice were determined. Oral, intraperitoneal or subcutaneous administrations of the compounds were successful for treatment. The doublet was effective for treatment of l

SUBMITTER: Vodnala SK 

PROVIDER: S-EPMC2713411 | biostudies-literature | 2009 Aug

REPOSITORIES: biostudies-literature