Immunoreactivity of ICAM-1 in human tumors, metastases and normal tissues.

ABSTRACT: Intercellular adhesion molecule-1 (ICAM-1) is implicated to play a role in cancer metastasis, and may serve as a diagnostic tool for tumor prognosis and progression as well as a target for therapeutic intervention. The aim of this study was to carry out a comprehensive survey of ICAM-1 immunoreactivity in normal, malignant and metastatic tissues. We assessed immunoreactivity of ICAM-1 in a total of 300 tissue cores from multiple tissue arrays of normal, malignant, and metastatic tissues by immunohistochemistry. We scored tissue samples for ICAM-1 immunoreactivity on a 0-3 scale, assessed the number of samples exhibiting infiltrating immune cells, and documented ICAM-1 immunoreactivity in some specific cell types. ICAM-1 expression in normal tissues was highest in spleen and absent in the c

SUBMITTER: Hayes SH 

PROVIDER: S-EPMC2713456 | biostudies-literature | 2009 Jun

REPOSITORIES: biostudies-literature