The traffic of the NKG2D/Dap10 receptor complex during natural killer (NK) cell activation.

ABSTRACT: NKG2D is an important activating receptor for triggering the NK cell cytotoxic activity, although chronic engagement of specific ligands by NKG2D is also known to provoke decreased cell surface expression of the receptor and compromised NK cell function. We have studied the dynamics of surface NKG2D expression and how exposure to the specific ligand major histocompatibility complex class I chain-related molecule B (MICB) affects receptor traffic and fate. While in the NKL cell line and "resting" NK cells NKG2D was found principally at the cell surface, in activated primary NK cells an intracellular pool of receptor could also be found recycling to the plasma membrane. Exposure of NK cells to targets expressing MICB resulted in degradation of approximately 50% of total NKG2D protein and lys

SUBMITTER: Roda-Navarro P 

PROVIDER: S-EPMC2713546 | biostudies-literature | 2009 Jun

REPOSITORIES: biostudies-literature