Chemo-enzymatic fluorination of unactivated organic compounds.

ABSTRACT: Fluorination has gained an increasingly important role in drug discovery and development. Here we describe a versatile strategy that combines cytochrome P450-catalyzed oxygenation with deoxofluorination to achieve mono- and polyfluorination of nonreactive sites in a variety of organic scaffolds. This procedure was applied for the rapid identification of fluorinated drug derivatives with enhanced membrane permeability.

SUBMITTER: Rentmeister A 

PROVIDER: S-EPMC2713661 | biostudies-literature | 2009 Jan

REPOSITORIES: biostudies-literature