Death-associated protein 3 is overexpressed in human thyroid oncocytic tumours.

ABSTRACT:

Background

The human death-associated protein 3 (hDAP3) is a GTP-binding constituent of the small subunit of the mitochondrial ribosome with a pro-apoptotic function.

Methods

A search through publicly available microarray data sets showed 337 genes potentially coregulated with the DAP3 gene. The promoter sequences of these 337 genes and 70 out of 85 mitochondrial ribosome genes were analysed in silico with the DAP3 gene promoter sequence. The mitochondrial role of DAP3 was also investigated in the thyroid tumours presenting various mitochondrial contents.

Results

The study revealed nine transcription factors presenting enriched motifs for these gene promoters, five of which are implicated in cellular growth (ELK1, ELK4, RUNX1, HOX11-CTF1, TAL1-ternary complex factor 3

SUBMITTER: Jacques C 

PROVIDER: S-EPMC2713694 | biostudies-literature | 2009 Jul

REPOSITORIES: biostudies-literature