Efficient three-component Strecker reaction of aldehydes/ketones via NHC-amidate palladium(II) complex catalysis.

ABSTRACT: A simple and efficient one-pot, three-component method has been developed for the synthesis of alpha-aminonitriles. This Strecker reaction is applicable for aldehydes and ketones with aliphatic or aromatic amines and trimethylsilyl cyanide in the presence of a palladium Lewis acid catalyst in dichloromethane solvent at room temperature.

SUBMITTER: Jarusiewicz J 

PROVIDER: S-EPMC2713785 | biostudies-literature | 2009 Apr

REPOSITORIES: biostudies-literature