Genetic polymorphisms of metastasis suppressor gene NME1 and breast cancer survival.

ABSTRACT:

Purpose

Ample evidence supports an important role of tumor metastasis suppressor genes in cancer metastatic processes. We evaluated the association of genetic polymorphisms of metastasis suppressor gene NME1 with breast cancer prognosis in a follow-up study of patients with primary breast cancer and further investigated the functions of these polymorphisms.

Experimental design

NME1 genotypes were analyzed in a cohort of 1,134 breast cancer patients recruited as part of the Shanghai Breast Cancer Study who were followed for a median of 7.1 years. In vitro biochemical analyses were carried out to examine the function of NME1 gene polymorphisms.

Results

Single nucleotide polymorphisms (SNP) in the promoter region of the NME1 gene were found to be associated with breast c

SUBMITTER: Qu S 

PROVIDER: S-EPMC2713865 | biostudies-literature | 2008 Aug

REPOSITORIES: biostudies-literature