Coordinated patterns of gene expressions for adult muscle build-up in transgenic mice expressing myostatin propeptide.

ABSTRACT:

Background

Skeletal muscle growth and maintenance are essential for human health. One of the muscle regulatory genes, namely myostatin, a member of transforming growth factor-beta, plays a dominant role in the genetic control of muscle mass. Myostatin is synthesized as a precursor protein, which generates the N-terminal propeptide and the C-terminal mature myostatin peptide by a post-translational cleavage event. Previously, transgenic over-expression of myostatin propeptide in skeletal muscle results in significant muscle growth in early stages of development. The objectives of present study were to further characterize muscle growth in later stages of life and to identify genes and their expression patterns that are responsible for adult muscle build-up by myostatin propeptide.

SUBMITTER: Zhao B 

PROVIDER: S-EPMC2713998 | biostudies-literature | 2009 Jul

REPOSITORIES: biostudies-literature