Habitual energy expenditure modifies the association between NOS3 gene polymorphisms and blood pressure.

ABSTRACT:

Background

The endothelial nitric-oxide synthase (NOS3) gene encodes the enzyme (eNOS) that synthesizes the molecule nitric oxide, which facilitates endothelium-dependent vasodilation in response to physical activity. Thus, energy expenditure may modify the association between the genetic variation at NOS3 and blood pressure.

Methods

To test this hypothesis, we genotyped 11 NOS3 polymorphisms, capturing all common variations, in 726 men and women from the Medical Research Council (MRC) Ely Study (age (mean +/- s.d.): 55 +/- 10 years, body mass index: 26.4 +/- 4.1 kg/m(2)). Habitual/non-resting energy expenditure (NREE) was assessed via individually calibrated heart rate monitoring over 4 days.

Results

The intronic variant, IVS25+15 [G-->A], was significantly associate

SUBMITTER: Vimaleswaran KS 

PROVIDER: S-EPMC2714087 | biostudies-literature | 2008 Mar

REPOSITORIES: biostudies-literature