Early and long-standing rheumatoid arthritis: distinct molecular signatures identified by gene-expression profiling in synovia.

ABSTRACT:

Introduction

Rheumatoid arthritis (RA) is a heterogeneous disease and its underlying molecular mechanisms are still poorly understood. Because previous microarray studies have only focused on long-standing (LS) RA compared to osteoarthritis, we aimed to compare the molecular profiles of early and LS RA versus control synovia.

Methods

Synovial biopsies were obtained by arthroscopy from 15 patients (4 early untreated RA, 4 treated LS RA and 7 controls, who had traumatic or mechanical lesions). Extracted mRNAs were used for large-scale gene-expression profiling. The different gene-expression combinations identified by comparison of profiles of early, LS RA and healthy synovia were linked to the biological processes involved in each situation.

Results

Three combinations o

SUBMITTER: Lequerre T 

PROVIDER: S-EPMC2714155 | biostudies-literature | 2009

REPOSITORIES: biostudies-literature