Amyloidogenic determinants are usually not buried.

ABSTRACT:

Background

Amyloidoses are a group of usually fatal diseases, probably caused by protein misfolding and subsequent aggregation into amyloid fibrillar deposits. The mechanisms involved in amyloid fibril formation are largely unknown and are the subject of current, intensive research. In an attempt to identify possible amyloidogenic regions in proteins for further experimental investigation, we have developed and present here a publicly available online tool that utilizes five different and independently published methods, to form a consensus prediction of amyloidogenic regions in proteins, using only protein primary structure data.

Results

It appears that the consensus prediction tool is slightly more objective than individual prediction methods alone and suggests several pre

SUBMITTER: Frousios KK 

PROVIDER: S-EPMC2714319 | biostudies-literature | 2009 Jul

REPOSITORIES: biostudies-literature