Does the clock make the poison? Circadian variation in response to pesticides.

ABSTRACT:

Background

Circadian clocks govern daily physiological and molecular rhythms, and putative rhythms in expression of xenobiotic metabolizing (XM) genes have been described in both insects and mammals. Such rhythms could have important consequences for outcomes of chemical exposures at different times of day. To determine whether reported XM gene expression rhythms result in functional rhythms, we examined daily profiles of enzyme activity and dose responses to the pesticides propoxur, deltamethrin, fipronil, and malathion.

Methodology/principal findings

Published microarray expression data were examined for temporal patterns. Male Drosophila were collected for ethoxycoumarin-O-deethylase (ECOD), esterase, glutathione-S-transferase (GST), and, and uridine 5'-diphosphoglucosylt

SUBMITTER: Hooven LA 

PROVIDER: S-EPMC2714471 | biostudies-literature | 2009 Jul

REPOSITORIES: biostudies-literature