Exploring temporal transcription regulation structure of Aspergillus fumigatus in heat shock by state space model.

ABSTRACT:

Background

The thermotolerance of Aspergillus fumigatus plays a critical role in mammalian and avian infections. Thus, the identification of its adaptation mechanism to higher temperature is very important for an efficient anti-fungal drug development as well as fundamental understanding of its pathogenesis. We explored the temporal transcription regulation structure of this pathogenic fungus under heat shock conditions using the time series microarray data reported by Nierman et al. (Nature 2005, 438:1151-1156).

Results

The estimated transcription regulation structure of A. fumigatus shows that the heat shock proteins are strongly negatively associated with central metabolic pathway genes such as the tricarboxylic acid cycle (TCA cycle) and carbohydrate metabolism. It was 6

SUBMITTER: Do JH 

PROVIDER: S-EPMC2714559 | biostudies-literature | 2009 Jul

REPOSITORIES: biostudies-literature