Human neutrophil peptides and phagocytic deficiency in bronchiectatic lungs.

ABSTRACT:

Rationale

A well-known clinical paradox is that severe bacterial infections persist in the lungs of patients with cystic fibrosis (CF) despite the abundance of polymorphonuclear neutrophils (PMN) and the presence of a high concentration of human neutrophil peptides (HNP), both of which are expected to kill the bacteria but fail to do so. The mechanisms remain unknown.

Objectives

This study examined several possible mechanisms to understand this paradox.

Methods

PMN were isolated from sputum and blood of subjects with and without CF or non-CF bronchiectasis for phagocytic assays. HNP isolated from patients with CF were used to stimulate healthy PMN followed by phagocytic tests.

Measurements and main results

PMN isolated from the sputum of the bronchiectatic pati

SUBMITTER: Voglis S 

PROVIDER: S-EPMC2714819 | biostudies-literature | 2009 Jul

REPOSITORIES: biostudies-literature