Discovery of cis-elements between sorghum and rice using co-expression and evolutionary conservation.

ABSTRACT:

Background

The spatiotemporal regulation of gene expression largely depends on the presence and absence of cis-regulatory sites in the promoter. In the economically highly important grass family, our knowledge of transcription factor binding sites and transcriptional networks is still very limited. With the completion of the sorghum genome and the available rice genome sequence, comparative promoter analyses now allow genome-scale detection of conserved cis-elements.

Results

In this study, we identified thousands of phylogenetic footprints conserved between orthologous rice and sorghum upstream regions that are supported by co-expression information derived from three different rice expression data sets. In a complementary approach, cis-motifs were discovered by their highly

SUBMITTER: Wang X 

PROVIDER: S-EPMC2714861 | biostudies-literature | 2009 Jun

REPOSITORIES: biostudies-literature