Ontology highlight
ABSTRACT:
SUBMITTER: Hanna J
PROVIDER: S-EPMC2714944 | biostudies-literature | 2009 Jun
REPOSITORIES: biostudies-literature
Cell stem cell 20090507 6
Embryonic stem cells (ESCs) are isolated from the inner cell mass (ICM) of blastocysts, whereas epiblast stem cells (EpiSCs) are derived from the postimplantation epiblast and display a restricted developmental potential. Here we characterize pluripotent states in the nonobese diabetic (NOD) mouse strain, which prior to this study was considered "nonpermissive" for ESC derivation. We find that NOD stem cells can be stabilized by providing constitutive expression of Klf4 or c-Myc or small molecul ...[more]