Expression of the peroxisome proliferator activated receptor gamma gene is repressed by DNA methylation in visceral adipose tissue of mouse models of diabetes.

ABSTRACT:

Background

Adipose tissues serve not only as a store for energy in the form of lipid, but also as endocrine tissues that regulates metabolic activities of the organism by secreting various kinds of hormones. Peroxisome proliferator activated receptor gamma (PPARgamma) is a key regulator of adipocyte differentiation that induces the expression of adipocyte-specific genes in preadipocytes and mediates their differentiation into adipocytes. Furthermore, PPARgamma has an important role to maintain the physiological function of mature adipocyte by controlling expressions of various genes properly. Therefore, any reduction in amount and activity of PPARgamma is linked to the pathogenesis of metabolic syndrome.

Results

In this study, we investigated the contribution of epigenetic t

SUBMITTER: Fujiki K 

PROVIDER: S-EPMC2715379 | biostudies-literature | 2009 Jul

REPOSITORIES: biostudies-literature