Dinuclear nickel complexes modeling the structure and function of the acetyl CoA synthase active site.

ABSTRACT: A dinuclear nickel complex with methyl and thiolate ligands, Ni(dadt(Et))Ni(Me)(SDmp) (2), has been synthesized as a dinuclear Ni(d)-Ni(p)-site model of acetyl-CoA synthase (ACS) (dadt(Et) is N,N'-diethyl-3,7-diazanonane-1,9-dithiolate; Dmp is 2,6-dimesitylphenyl). Complex 2 was prepared via 2 methods: (i) ligand substitution of a dinuclear Ni(II)-Ni(II) cation complex [Ni(dadt(Et)) Ni(tmtu)2] (OTf)2 (1) with MeMgBr and KSDmp (tmtu is tetramethylthiourea), (ii) methyl transfer from methylcobaloxime Co(dmgBF2)2(Me)(Py) (5) to a Ni(II)-Ni(0) complex such as [Ni(dadt(Et))Ni(cod)] (3), generated in situ from Ni(dadt(Et)) and Ni(cod)(2), followed by addition of KSDmp (cod is 1,5-cyclooctadiene; dmgBF2 is difluoroboryl-dimethylglyoximate). Method ii models the formation of Nip-Me species propose

SUBMITTER: Ito M 

PROVIDER: S-EPMC2715534 | biostudies-literature | 2009 Jul

REPOSITORIES: biostudies-literature