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Daptomycin rapidly penetrates a Staphylococcus epidermidis biofilm.

ABSTRACT: Fluorescently tagged daptomycin accessed the interior of Staphylococcus epidermidis biofilm cell clusters within minutes. The diffusion coefficient of daptomycin in the biofilm was 28% of its value in pure water. Daptomycin activity against staphylococci embedded in biofilms is unlikely to be limited by penetration of the antibiotic into the biofilm.

SUBMITTER: Stewart PS 

PROVIDER: S-EPMC2715639 | biostudies-literature | 2009 Aug

REPOSITORIES: biostudies-literature

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Daptomycin rapidly penetrates a Staphylococcus epidermidis biofilm.

Stewart Philip S PS   Davison William M WM   Steenbergen Judith N JN  

Antimicrobial agents and chemotherapy 20090518 8

Fluorescently tagged daptomycin accessed the interior of Staphylococcus epidermidis biofilm cell clusters within minutes. The diffusion coefficient of daptomycin in the biofilm was 28% of its value in pure water. Daptomycin activity against staphylococci embedded in biofilms is unlikely to be limited by penetration of the antibiotic into the biofilm. ...[more]

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