The Staphylococcus aureus LytSR two-component regulatory system affects biofilm formation.

ABSTRACT: Studies of the Staphylococcus aureus LytSR two-component regulatory system have led to the identification of the cid and lrg operons, which affect murein hydrolase activity, stationary-phase survival, antibiotic tolerance, and biofilm formation. The cid gene products enhance murein hydrolase activity and antibiotic tolerance whereas the lrg gene products inhibit these processes in a manner believed to be analogous to bacteriophage-encoded holins and antiholins, respectively. Importantly, these operons have been shown to play significant roles in biofilm development by controlling the release of genomic DNA, which then becomes an important structural component of the biofilm matrix. To determine the role of LytSR in biofilm development, a lytS knockout mutant was generated from a clinical S

SUBMITTER: Sharma-Kuinkel BK 

PROVIDER: S-EPMC2715716 | biostudies-literature | 2009 Aug

REPOSITORIES: biostudies-literature