Ontology highlight
ABSTRACT:
SUBMITTER: Curanovic D
PROVIDER: S-EPMC2715761 | biostudies-literature | 2009 Aug
REPOSITORIES: biostudies-literature
Curanovic Dusica D Enquist Lynn W LW
Journal of virology 20090603 16
Transneuronal spread of pseudorabies virus (PRV) is a multistep process that requires several virally encoded proteins. Previous studies have shown that PRV glycoprotein B (gB), a component of the viral fusion machinery, is required for the transmission of infection to postsynaptic, second-order neurons. We sought to identify the gB-mediated step in viral transmission. We determined that gB is not required for the sorting of virions into axons of infected neurons, anterograde transport, or the r ...[more]