Human disease-drug network based on genomic expression profiles.

ABSTRACT:

Background

Drug repositioning offers the possibility of faster development times and reduced risks in drug discovery. With the rapid development of high-throughput technologies and ever-increasing accumulation of whole genome-level datasets, an increasing number of diseases and drugs can be comprehensively characterized by the changes they induce in gene expression, protein, metabolites and phenotypes.

Methodology/principal findings

We performed a systematic, large-scale analysis of genomic expression profiles of human diseases and drugs to create a disease-drug network. A network of 170,027 significant interactions was extracted from the approximately 24.5 million comparisons between approximately 7,000 publicly available transcriptomic profiles. The network includes 645 di

SUBMITTER: Hu G 

PROVIDER: S-EPMC2715883 | biostudies-literature | 2009 Aug

REPOSITORIES: biostudies-literature