Maternal diabetes alters transcriptional programs in the developing embryo.

ABSTRACT:

Background

Maternal diabetes is a well-known risk factor for birth defects, such as heart defects and neural tube defects. The causative molecular mechanisms in the developing embryo are currently unknown, and the pathogenesis of developmental abnormalities during diabetic pregnancy is not well understood. We hypothesized that the developmental defects are due to alterations in critical developmental pathways, possibly as a result of altered gene expression. We here report results from gene expression profiling of exposed embryos from a mouse diabetes model.

Results

In comparison to normal embryos at mid-gestation, we find significantly altered gene expression levels in diabetes-exposed embryos. Independent validation of altered expression was obtained by quantitative Real T

SUBMITTER: Pavlinkova G 

PROVIDER: S-EPMC2715936 | biostudies-literature | 2009 Jun

REPOSITORIES: biostudies-literature