No association of CDK5 genetic variants with Alzheimer's disease risk.

ABSTRACT:

Background

As cyclin-dependent kinase 5 (CDK5) has been implicated in the abnormal hyperphosphorylation of tau in Alzheimer's disease (AD) brain, and the development of neurofibrillary tangles, we examined the contribution of this gene to the susceptibility for AD.

Methods

We examined genetic variations of CDK5 by genotyping haplotype tagging SNPs (htSNPs) (rs9278, rs2069459, rs891507, rs2069454, rs1549759 and rs2069442) in a group of 408 Spanish AD cases and 444 controls.

Results

There were no differences in the genotypic, allelic or haplotypic distributions between cases and controls in the overall analysis or after stratification by APOE epsilon4 allele.

Conclusion

Our negative findings in the Spanish population argue against the hypothesis that CDK5 genetic

SUBMITTER: Vazquez-Higuera JL 

PROVIDER: S-EPMC2716333 | biostudies-literature | 2009 Jul

REPOSITORIES: biostudies-literature