Ensemble approach to predict specificity determinants: benchmarking and validation.

ABSTRACT:

Background

It is extremely important and challenging to identify the sites that are responsible for functional specification or diversification in protein families. In this study, a rigorous comparative benchmarking protocol was employed to provide a reliable evaluation of methods which predict the specificity determining sites. Subsequently, three best performing methods were applied to identify new potential specificity determining sites through ensemble approach and common agreement of their prediction results.

Results

It was shown that the analysis of structural characteristics of predicted specificity determining sites might provide the means to validate their prediction accuracy. For example, we found that for smaller distances it holds true that the more reliable the

SUBMITTER: Chakrabarti S 

PROVIDER: S-EPMC2716344 | biostudies-literature | 2009 Jul

REPOSITORIES: biostudies-literature