A gene signature for post-infectious chronic fatigue syndrome.

ABSTRACT:

Background

At present, there are no clinically reliable disease markers for chronic fatigue syndrome. DNA chip microarray technology provides a method for examining the differential expression of mRNA from a large number of genes. Our hypothesis was that a gene expression signature, generated by microarray assays, could help identify genes which are dysregulated in patients with post-infectious CFS and so help identify biomarkers for the condition.

Methods

Human genome-wide Affymetrix GeneChip arrays (39,000 transcripts derived from 33,000 gene sequences) were used to compare the levels of gene expression in the peripheral blood mononuclear cells of male patients with post-infectious chronic fatigue (n = 8) and male healthy control subjects (n = 7).

Results

Patients a

SUBMITTER: Gow JW 

PROVIDER: S-EPMC2716361 | biostudies-literature | 2009 Jun

REPOSITORIES: biostudies-literature