Modelling dominance in a flexible intercross analysis.

ABSTRACT:

Background

The aim of this paper is to develop a flexible model for analysis of quantitative trait loci (QTL) in outbred line crosses, which includes both additive and dominance effects. Our flexible intercross analysis (FIA) model accounts for QTL that are not fixed within founder lines and is based on the variance component framework. Genome scans with FIA are performed using a score statistic, which does not require variance component estimation.

Results

Simulations of a pedigree with 800 F2 individuals showed that the power of FIA including both additive and dominance effects was almost 50% for a QTL with equal allele frequencies in both lines with complete dominance and a moderate effect, whereas the power of a traditional regression model was equal to the chosen signif

SUBMITTER: Ronnegard L 

PROVIDER: S-EPMC2716366 | biostudies-literature | 2009 Jun

REPOSITORIES: biostudies-literature