Translational repression contributes greater noise to gene expression than transcriptional repression.

ABSTRACT: Stochastic effects in gene expression may result in different physiological states of individual cells, with consequences for pathogen survival and artificial gene network design. We studied the contributions of a regulatory factor to gene expression noise in four basic mechanisms of negative gene expression control: 1), transcriptional regulation by a protein repressor, 2), translational repression by a protein; 3), transcriptional repression by RNA; and 4), RNA interference with the translation. We investigated a general model of a two-gene network, using the chemical master equation and a moment generating function approach. We compared the expression noise of genes with the same effective transcription and translation initiation rates resulting from the action of different repressors,

SUBMITTER: Komorowski M 

PROVIDER: S-EPMC2716471 | biostudies-literature | 2009 Jan

REPOSITORIES: biostudies-literature