Gene expression in murine mammary epithelial stem cell-like cells shows similarities to human breast cancer gene expression.

ABSTRACT:

Introduction

Mammary stem cells are bipotential and suggested to be the origin of breast cancer development, but are elusive and vaguely characterized. Breast tumors can be divided into subgroups, each one requiring specific treatment. To determine a possible association between mammary stem cells and breast cancer, a detailed characterization of the transcriptome in mammary stem cells is essential.

Methods

We have used a murine mammary epithelial stem-like cell line (HC11) and made a thorough investigation of global gene-expression changes during stepwise differentiation using dual-color comparative microarray technique. Subsequently, we have performed a cross-species comparison to reveal conserved gene expression between stem cells and subtype-specific and prognosis gene s

SUBMITTER: Williams C 

PROVIDER: S-EPMC2716494 | biostudies-literature | 2009

REPOSITORIES: biostudies-literature