PI-3 kinase activity is necessary for ERK1/2-induced disruption of mammary epithelial architecture.

ABSTRACT:

Introduction

Epithelial tumors, including breast cancer, are being identified and treated at earlier stages of tumor development because of technological advances in screening and detection methods. It is likely that early-stage epithelial tumors, such as mammary ductal carcinoma in situ (DCIS), will be amenable to new and more efficacious diagnostic tests and forms of therapy. However, our limited understanding of the underlying molecular mechanisms of early-stage epithelial tumor growth has hampered the development of new forms treatment and preventative therapy.

Methods

The Raf-MEK1/2-ERK1/2 mitogen-activated protein kinase module is activated by stimuli complicit in mammary neoplastic progression. We have recently demonstrated that the activation of ERK1/2 induces a non-

SUBMITTER: Pearson GW 

PROVIDER: S-EPMC2716497 | biostudies-literature | 2009

REPOSITORIES: biostudies-literature