Frequent loss of endothelin-3 (EDN3) expression due to epigenetic inactivation in human breast cancer.

ABSTRACT:

Introduction

Endothelin (EDN) signalling plays a crucial role in cell differentiation, proliferation and migration processes. There is compelling evidence that altered EDN signalling is involved in carcinogenesis by modulating cell survival and promoting invasiveness. To date, most reports have focused on the oncogenic potential of EDN1 and EDN2, both of which are overexpressed in various tumour entities. Here, we aimed at a first comprehensive analysis on EDN3 expression and its implication in human breast cancer.

Methods

EDN3 mRNA expression was assessed by Northern blotting in normal human tissues (n = 9) as well as in matched pairs of normal and tumourous tissues from breast specimens (n = 50). EDN3 mRNA expression in breast cancer was further validated by real-time poly

SUBMITTER: Wiesmann F 

PROVIDER: S-EPMC2716502 | biostudies-literature | 2009

REPOSITORIES: biostudies-literature