Role of translational coupling in robustness of bacterial chemotaxis pathway.

ABSTRACT: Chemotaxis allows bacteria to colonize their environment more efficiently and to find optimal growth conditions, and is consequently under strong evolutionary selection. Theoretical and experimental analyses of bacterial chemotaxis suggested that the pathway has been evolutionarily optimized to produce robust output under conditions of such physiological perturbations as stochastic intercellular variations in protein levels while at the same time minimizing complexity and cost of protein expression. Pathway topology in Escherichia coli apparently evolved to produce an invariant output under concerted variations in protein levels, consistent with experimentally observed transcriptional coupling of chemotaxis genes. Here, we show that the pathway robustness is further enhanced through the pa

SUBMITTER: Lovdok L 

PROVIDER: S-EPMC2716512 | biostudies-literature | 2009 Aug

REPOSITORIES: biostudies-literature