Limb immobilization induces a coordinate down-regulation of mitochondrial and other metabolic pathways in men and women.

ABSTRACT: Advancements in animal models and cell culture techniques have been invaluable in the elucidation of the molecular mechanisms that regulate muscle atrophy. However, few studies have examined muscle atrophy in humans using modern experimental techniques. The purpose of this study was to examine changes in global gene transcription during immobilization-induced muscle atrophy in humans and then explore the effects of the most prominent transcriptional alterations on protein expression and function. Healthy men and women (N = 24) were subjected to two weeks of unilateral limb immobilization, with muscle biopsies obtained before, after 48 hours (48 H) and 14 days (14 D) of immobilization. Muscle cross sectional area (approximately 5%) and strength (10-20%) were significantly reduced in men and

SUBMITTER: Abadi A 

PROVIDER: S-EPMC2716517 | biostudies-literature | 2009 Aug

REPOSITORIES: biostudies-literature