Blocking TLR2 activity attenuates pulmonary metastases of tumor.

ABSTRACT:

Background

Metastasis is the most pivotal cause of mortality in cancer patients. Immune tolerance plays a crucial role in tumor progression and metastasis.

Methods and findings

In this study, we investigated the potential roles and mechanisms of TLR2 signaling on tumor metastasis in a mouse model of intravenously injected B16 melanoma cells. Multiple subtypes of TLRs were expressed on B16 cells and several human cancer cell lines; TLR2 mediated the invasive activity of these cells. High metastatic B16 cells released more heat shock protein 60 than poor metastatic B16-F1 cells. Importantly, heat shock protein 60 released by tumor cells caused a persistent activation of TLR2 and was critical in the constitutive activation of transcription factor Stat3, leading to the release o

SUBMITTER: Yang HZ 

PROVIDER: S-EPMC2716531 | biostudies-literature | 2009 Aug

REPOSITORIES: biostudies-literature