Serotonin transporter polymorphisms in patients with portopulmonary hypertension.

ABSTRACT:

Background

The long allele of a functional promoter polymorphism in the serotonin transporter (SERT) is associated with an increased risk of some forms of pulmonary arterial hypertension. We hypothesized that the long allele or other polymorphisms in SERT would be associated with an increased risk of portopulmonary hypertension (PPHTN) in patients with advanced liver disease.

Methods

We performed a multicenter case-control study. Subjects undergoing liver transplant evaluation at seven centers were prospectively screened for the presence of PPHTN using transthoracic echocardiography. PPHTN was confirmed by right heart catheterization using standard criteria.

Results

The study sample included 30 case patients with PPHTN and 109 control subjects with advanced liver dise

SUBMITTER: Roberts KE 

PROVIDER: S-EPMC2716711 | biostudies-literature | 2009 Jun

REPOSITORIES: biostudies-literature