Ontology highlight
ABSTRACT:
SUBMITTER: Zheng G
PROVIDER: S-EPMC2716958 | biostudies-literature | 2009 Aug
REPOSITORIES: biostudies-literature
The American journal of pathology 20090709 2
Epithelial-mesenchymal transition (EMT) plays an important role in organ fibrosis, including that of the kidney. Loss of E-cadherin expression is a hallmark of EMT; however, whether the loss of E-cadherin is a consequence or a cause of EMT remains unknown, especially in the renal system. In this study, we show that transforming growth factor (TGF)-beta1-induced EMT in renal tubular epithelial cells is dependent on proteolysis. Matrix metalloproteinase-mediated E-cadherin disruption led directly ...[more]