Infiltrating CTLs in human glioblastoma establish immunological synapses with tumorigenic cells.

ABSTRACT: The immunological synapse between T cells and tumor cells is believed to be important for effective tumor clearance. However, the immunological synapse has never been imaged or analyzed in detail in human tissue. In this work, intercellular interactions between T cells and tumor cells were analyzed in detail in human glioblastoma. After characterization of the population of infiltrating T cells by multiple immunofluorescence staining and stereological quantification, the microanatomy of T cell-tumor cell intercellular communication was analyzed in detail using confocal microscopy and three-dimensional rendering. Cytotoxic T lymphocytes that infiltrated human glioblastoma underwent rearrangement when in contact with tumor cells, to form a three-dimensional structure in the intercellular con

SUBMITTER: Barcia C 

PROVIDER: S-EPMC2716973 | biostudies-literature | 2009 Aug

REPOSITORIES: biostudies-literature